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In addition, the NOD-like receptor pyrin domain-containing protein 3 (NLRP3) inflammasome, a multiprotein signalling complex, is also assembled and activated in response to damage-associated molecular patterns (DAMPs), which then catalyzes active forms of pro-inflammatory cytokines, such as IL-1 and IL-18

As a matter of fact, taking into full account the intricacy of the numerous regulatory mechanisms involved in OS control as well as the complex interplay between the many events that contribute to the progressive degeneration and death of MNs, future neuroprotective pharmacological therapies will likely need to aim for an integrated treatment, acting on several levels to limit the progression of the disease

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