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The practical difference that matters most today, though, is regulatory: tirzepatide is an approved medicine you can be prescribed, while retatrutide is still an investigational compound being evaluated in clinical trials

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The administration of high doses of lipoic acid by injection to rats decreased the activity of two biotin-dependent enzymes by about 30%-35% (122), but it is not known whether oral or intravenous lipoic acid supplementation substantially increases the requirement for biotin in humans (123)