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While research shows some benefits (for example improved sleep efficiency, reduced sleep latency) in controlled settings, there are still questions around long-term safety, especially in healthy subjects or non-clinical contexts

131 Similarly, sinomenine exhibits hepatoprotective effects through suppression of NLRP3 inflammasome activation, reduction of oxidative stress, and inhibition of the HMGB1/TLR4/NF-B pathway

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