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The 3.0mL option creates a 10mg/mL concentration that works for the 4mg and 8mg dose levels but requires splitting at 12mg

This observation is consistent with previously reported mechanisms of the casein kinase 1 family, which are capable of phosphorylating non-primed substrates but do so far more efficiently when an upstream priming phosphorylation is present 75,76,77

Inoda et al

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