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Da Silva, R

B12 shots get injected right into the muscle so you can begin to feel the effects immediately

While this effect appears to be related to the magnitude and rapidity of glucose lowering rather than a direct effect of the medication itself, patients with a history of diabetic retinopathy should undergo careful ophthalmologic evaluation before and during treatment, and the potential risks should be weighed against the expected benefits of improved glycemic control

Intramuscular injections are reserved for cases where oral treatment is insufficient, poorly tolerated, or where deficiency has caused neurological complications