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This indicates that older adults might be more susceptible to AKI during periods of hypoperfusion, as they display a weakened vasodilatory capacity combined with an intact, or potentially augmented, vasoconstrictive response ( Furthermore, a study conducted by the TRIBE-AKI Consortium involving 1444 patients undergoing cardiac surgery showed that postoperative VEGF and placental growth factor (PGF) levels were inversely linked to AKI risk and mortality, whereas VEGR levels were positively associated with AKI and mortality (Mansour et al., 2019)

According to the Global Burden of Disease (GBD) Study 2019, the number of individuals living with PD more than doubled from 2.5 million in 1990 to over 6.1 million in 2016, with projections exceeding 12 million by 2040 (Zhong and Zhu, 2022)