A growing amount of studies have demonstrated that ferroptosis participates in the progression of many different diseases such as cancer [15], Alzheimers disease [16], Parkinsons disease [17], traumatic brain injury [18], rheumatoid arthritis (RA) [19], ischemia-reperfusion injury [20] and intervertebral disc degeneration [21]
In conclusion, it is necessary to explore the synergistic effects of existing natural compounds, reduce the limitations of single therapies, optimize dosing regimens, and carry out large-scale long-term studies
J Endocrinol Invest (2017) 40(3):2817
Simultaneously, melanocytes express co-stimulatory molecules (e.g., CD40, CD80) and adhesion molecules (e.g., ICAM-1), enabling them to present self-antigens to T cells, thereby promoting T cell proliferation and activation, ultimately contributing to vitiligo progression