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doi: 10.1016/j.brainresbull.2018.11.013

IC/BPS patients may experience a more constant urge to void as opposed to the classic International Continence Society definition of a "compelling need to urinate which is difficult to postpone." 56, 57 Typically IC/BPS patients void to avoid or to relieve pain

This lowers the production of glutathione, which requires cysteine rather than cystine, and now there is a vicious circle mechanism that preserves this malfunction and keeps you sick That's the basic biochemical mechanism of CFS everything else flows from this Here's how I believe the fatigue occurs: The cells have little powerplants in them, called mitochondria

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