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6-OHDA has also been shown to impair the mitochondrial respiratory chain by inhibiting complex I (Glinka and Youdim, 1995)

Here is what each one does and why the combination matters

[DOI] [PMC free article] [PubMed] [Google Scholar] 420.Ju W.K., Kim K.Y., Lindsey J.D., Angert M., Duong-Polk K.X., Scott R.T., et al

Indirect evidence supporting a possible benefit of methylation cycle supplements include findings of increased homocysteine in the cerebrospinal fluid of CFS and fibromyalgia patients