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Notably, for some forms of plasticity in interneurons, the relation between the magnitude of [Ca 2+ ] i rise and induction of LTP or LTD could be different from that in pyramidal neurons, e.g., lacking the LTD window altogether (Le Roux et al., 2013) or even the inverse (whereby lower influx induces LTP and LTD occurring after higher rises)

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Enhanced Energy Expenditure via NNMT Inhibition : In preclinical models, 5-Amino-1MQ increased whole-body metabolic rate by redirecting cellular resources away from fat storage and toward active ATP production

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