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In a related analysis, GHK was noted for its ability to reverse, in vitro, an aggressive gene-expression signature associated with metastatic behavior in certain tumor-cell datasets a striking observation that is nonetheless purely computational/in-vitro and not a therapeutic claim, and one that should be read alongside the founding finding that the same peptide can stimulate growth in neoplastic cells

This makes it a useful compound for research on therapies for growth hormone deficiency and its effect on bone density

This theory faces contradictions, such as HPA axis hypofunction being limited to certain patients, no early-stage changes in ME/CFS, and heightened immunosuppressive effects of glucocorticoids in these patients

Aging and the regulation of luteinizing hormone in C57BL/6J mice: impaired elevations after ovariectomy and spontaneous elevations at advanced ages