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Its research profile makes it relevant to controlled investigations involving methylation-linked metabolism, energy-balance signaling, metabolic stress response, adipose-associated cellular systems, and cellular adaptation under nutrient-sensitive conditions

[3] Patients with deficiencies often experience fatigue, cognitive or nerve impairments, and slow recovery

as a key regulator of mitochondrial biogenesis, PGC1 enhances mitochondrial function in myoblasts, supplies sufficient energy for differentiation, and regulates the transcription of myogenic genes to accelerate myotube maturation

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