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Velavan, T

Evidence-Based Complementary and Alternative Medicine, 5(1), 27-35

In contrast to histamine which is preformed in a one step reaction by decarboxylation of histidine predominantly in mast cells and basophils, cysteinyl leukotrienes (CysLTs) represent a class of immune-modulating eicosanoids which are rapidly synthesized de novo in a multi-step cascade in response to various stimuli mainly in basophils, eosinophils and mast cells and to a lower extend in macrophages and dendritic cells [14, 15]

When evaluating diagnostic properties of DPS p-tau217, we assessed cutoffs derived with 90% sensitivity, 90% specificity or maximum Youdens Index for CSF or venous plasma biomarker positivity and computed their respective NPV and PPV based on the prevalence of biomarker positivity in the subset of participants with available data for each analysis