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Additional information Peer review information Nature Metabolism thanks Dominique Langin and the other, anonymous reviewers for their contribution to the peer review of this work

GHK-CU tends to be gentlest

Vitamin B12 injections can help by: Restoring energy balance so you feel less drained during treatment Supporting nutritional health , since reduced appetite can sometimes lead to nutrient deficiencies Enhancing metabolism to complement the appetite-suppressing effects of GLP-1 therapy Promoting overall wellness and vitality as you lose weight Together, GLP-1 medications + Vitamin B12 injections create a more balanced, supportive weight loss plan , helping you reach your goals more effectively

All controlled studies referenced below were conducted in cell culture (3T3-L1 adipocytes, primary muscle stem cells) or rodent models (diet-induced obese mice, aged C57BL/6J mice)