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According to the vascular depression hypothesis, vascular damage in the frontal and subcortical brain regions, which are involved in mood regulation, might lead to depression in older individuals (117)

The physiological fatigue that anyone is familiar with is an internal state that prevents over-exertion and allows re-allocation and restoration of energetic resources

7t) and offer a previously unappreciated view for future studies to determine whether pre-symptomatic changes involving the glutathioneascorbate metabolism pathway, particularly GSTO2, occur in cell types vulnerable to neurodegenerative conditions such as HD or SCAs

Smith, B