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According to the Centers for Disease Control and Prevention (CDC), prescription painkillers containing both acetaminophen and opioids are frequently misused, leading to opioid use disorders and escalating the ongoing addiction crisis in the U.S

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Due to the dual role of Nrf2 (pro-oncogenic and anti-oncogenic) in cancer patients, other factors, such as metabolic genes, proliferative genes, and angiogenesis genes, should also be considered for inhibiting Nrf2 through Nrf2 inhibitors (Almeida et al., 2020