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CMS121 was shown to improve memory, and cognitive function in APPswe/PS1 E9 double transgenic mice ( LOX inhibitors 5-Lipoxygenase (5LO) is widely expressed in central nervous system neurons, and its levels increase in an age-dependent manner in the hippocampus and cortex, two brain regions prone to neurodegenerative damage

GPX4 serves a central role in inhibiting ferroptosis by reducing lipid peroxidation and preserving cell membrane integrity

In addition, neuroimaging studies of patients with ADHD reported an elevated level of striatal dopamine transporter activity, which is reverted by the administration of methylphenidate [59, 60]

From the perspective of TCM, treatment must achieve treating both the symptoms and the root causes, correspondingly, we propose further exploration of potential interventions targeting pathogeneses involved in epileptogenesis from TCM, but not just focus on neural inhibitory mechanisms