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To further probe the catalytic mechanism of arGSTs, we conducted quantum mechanics/molecular mechanics (QM/MM) calculations based on the ternary complex of GSH, ()-catechin ( 12 ) and Pt GSTF8

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Although targeting macropinocytosis could be a key strategy for overcoming resistance to glutamine uptake blockade, further studies are necessary to examine whether macropinocytosis can overcome tumor cell resistance to glutamine antimetabolites or GLS inhibitors that target enzymes involved directly in glutamine metabolism