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Synaptotagmin 1 (Syt1) is a calcium-binding protein that plays a critical role in both exocytosis and endocytosis of SVs 6 , and that has been used as key target for studying SV recycling 7

These findings provided direct support for our hypothesis that the microenvironment-triggered disintegration of cPLT-protein complexes into small sized protein units could facilitate the penetration of protein nanodrugs in the plaque stroma

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