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10.1002/smll.201001832 11 Angele-MartinezC.AmeerF

AOD-9604 Research Protocols & Administration Dosing in Published Research Research investigations have employed diverse AOD-9604 doses across species and administration routes: Rodent studies: 250-500 mcg/kg orally or intraperitoneally was most common for obesity research Rabbit models: 0.25 mg per joint for osteoarthritis studies (intra-articular injection) Pig pharmacokinetic studies: 1.5 mg/kg IV and 2 mg/kg oral for metabolism characterization Human clinical trials: Oral doses of 0.25-10 mg daily

Key factors to consider during assessment include: Duration and severity of symptoms Presence of underlying conditions that may affect B12 absorption Previous treatments or supplements that may influence B12 status Choosing Between Oral and Injectable Forms The choice between oral and injectable B12 depends on several factors

The noradrenaline quantification were performed by using mouse noradrenaline ELISA kit (Meimian, MM-0876)