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According to the FDA labels, nausea occurs in 17-25% of patients taking Zepbound and 12-24% taking Mounjaro, with vomiting and diarrhea also commonly reported

Thiazolidinediones (e.g., pioglitazone) improve insulin sensitivity via peroxisome proliferator-activated receptor gamma (PPAR-) modulation (Zhiwei et al., 2021)