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However, at excessive levels, ROS exert toxic effects and directly oxidize biological macromolecules, such as proteins, nucleic acids and lipids, further exacerbating the development of inflammatory responses and causing various inflammatory diseases

Humanized mAb Olokizumab (CDP6038), or OKZ, binds to the IL-6 receptor and showed favorable results in phase III with a significant reduction in DAS28 from baseline after 12 weeks of treatment [104]

Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders

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