Pay in 4 interest-free payments of $5.75 Learn more
Ships within 48 hours · Estimated delivery Jul 30 - Aug 4
Neoplasma, 39, 337342
OXIDATION TOXIC PATHWAY (CYP2E1 enzyme) Only 5-10% of acetaminophen in healthy non-pregnant adults INCREASES by 80% during pregnancy[] Creates NAPQI (N-acetyl-p-benzoquinone imine)the toxic metabolite NAPQI formation 43% HIGHER in first trimester[] NAPQI must be immediately neutralized by glutathione When glutathione is depleted, NAPQI causes cellular damage Crosses the placenta and damages fetal brain HOW PREGNANCY CHANGES ACETAMINOPHEN METABOLISM METABOLIC PATHWAY CHANGES DURING PREGNANCY[] Human pharmacokinetic studies reveal dramatic shifts in how pregnant women metabolize acetaminophen: Oxidation to NAPQI (Toxic Pathway) INCREASES by 80% The Brookhuis et al
The reduced form GSH is the active form of the molecule, it is the most abundant and it is found inside the cells in millimolar concentrations in the range of 110 mM (highest concentration in liver) (Figure 1) which provides its reductive power
Ultrastructural distribution of glutathione demonstrated by Otulak-Kozie et al
US$ 25.25
US$ 24.38
US$ 23.78
US$ 24.24
US$ 22.14
US$ 21.46
US$ 24.11
US$ 27.48