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38 This pain commonly presents as spontaneous burning sensations in the feet, and patients may also report positive sensory symptoms such as brush-evoked allodynia (pain from normally non-painful stimuli) and paresthesias, which are often accompanied by sensory loss, leading patients to describe the paradox of their feet being continuously painful yet insensate to touch

Following apoptotic stimuli (e.g., DNA damage, growth factor deficiency), Bax/Bak forms oligomeric complexes that insert into the mitochondrial outer membrane, leading to changes in mitochondrial osmotic pressure

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10.1007/s00535-020-01750-3 162 SzczepanowskaJ.MalinskaD.WieckowskiM