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The half-life sits around 5 days, which is why weekly dosing works

The free radical theory and the mitochondrial theory propose that elevated free radicals (oxidative stress) and mitochondrial dysfunction, respectively, are at the core of geriatric aging

doi: 10.1016/s2666-5247(23)00067-8 73 DarvishiE.OmidiM.BushehriA

MNA cells rely on an elevated antioxidant response through the Xc-/glutathione (GSH) pathway to scavenge lipid hydroperoxides, a by-product formed from excess H 2 O 2 ( We recently discovered in a drug screen that Diphenyleneiodonium chloride (DPI) selectively induces cell death of MNA NB cells in vitro and decreases tumor growth in vivo ( Although precision therapy for individual patients remains limited, combination therapy has the potential to enhance treatment efficacy while potentially reducing reliance on highly toxic chemotherapy ( 2 Results 2.1 MitoQ induces cell death and differentiation in neuroblastoma cells and potentiates DPI-induced cytotoxicity To investigate whether enhanced ROS production mediates the cytotoxic effects of DPI, we used MitoQ, a ROS scavenger that selectively accumulates in mitochondria ( Supplementary Figure S1 )