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Astrocyte-specific Bmal1 deletion induces astrocyte activation in vitro and in vivo, mediated in part by suppression of glutathione-s-transferase signaling

(This effect was primarily explained by the ability of copper to interfere with HodgkinHuxley conductances rather than the synaptic effects of copper [255].) Using a second-generation fluorescent copper sensor in combination with XFM, Dodani et al

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In Phase 3 trials, CagriSema achieved 20-22% average weight losssignificantly more than either component alone