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Through targeted modification of its parent core structure, researchers have found that the introduction of specific functional groups can significantly enhance bioavailability while maintaining the core pharmacological activity ( in silico methods of molecular docking to map steric/electronic requirements of binding pockets in biological targets could systematically elucidate appropriate rational designs ( Preclinical studies are urgently needed to validate caudatins efficacy in a wider range of cancer models and inflammatory diseases ( In vitro and in vivo studies may suggest or provide a useful degree of efficacy, but do not provide a complete representation of the clinical heterogeneity present in human disease