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59 During the disease, an increase in active inflammatory cytokines such as IL-12, IFN-, IL-1 and TNF- is observed, while Th2-related cytokines such as Il-10 and IL-13 decrease

More importantly perhaps, the subjective effects of the ayahuasca peaked at about 2 hrs after ingestion, and had declined almost to baseline 4 hrs later

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Essentially, the decrease appears to result from the fact that the tobacco companies have been packing considerably less tobacco into their cigarettes than they formerly did, even though their cigarettes have tended to get longer