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Curr Issues Mol Biol 45(12):93429353

In terms of the therapeutic efficacy, two patients experienced no changes with treatment and four subjects were rated to have minimal therapeutic efficacy

The mechanisms by which estrogen promotes wound healing involve modulation of inflammation, oxidative stress, proteolysis, cell migration, proliferation, and angiogenesis, processes that were shown to be improved with the use of topical SERMs, estrogen precursors like DHEA, synthetic estrogens, and regenerative medicine approaches targeting estrogen signaling and biosynthesis

Apply up to 10ml per session every 8 days, or as directed by a professional