Composed of the light chain subunit solute carrier family 7 member 11 (SLC7A11) and the heavy chain subunit SLC3A2, System Xc imports extracellular cystine, which is then rapidly reduced to cysteine intracellularly (28)
At the same time, exosomal vesicles can carry inflammatory factors, enhancing inflammatory responses through intercellular communication, altering the endometrial environment, and increasing the risk of recurrent miscarriage
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Deficiency of glutaredoxin 5 reveals Fe-S clusters are required for vertebrate haem synthesis