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Seminal oxidative stress indices Few studies demonstrated improvement in OS as determined by reduction of levels of malonaldehyde (MDA), a lipid peroxidation byproduct following therapy with Vitamin C, vitamin E, beta-carotene, zinc, selenium, and NAC when used alone or in combination (107111)

Finally, a four-year, multicenter, clinical trial in 421 diabetic patients with distal symmetric sensorimotor polyneuropathy found no difference between oral administration of 600 mg/day of lipoic and placebo on the primary endpoint, a composite score that assessed neuropathic impairment of the lower limbs and nerve conduction (78)

When the antioxidant is administered intravenously as opposed to orally, it is completely and substantially more quickly absorbed