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The mechanism connects back to the innate repair receptor

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This extraordinary sensitivity is mediated by the activation of the mechanosensitive transient receptor potential cation channel subfamily M member 7 (TRPM7), which in turn triggers calcium ions (Ca 2+ ) influx, thereby promoting a thicker actomyosin cortex [50]

The evolution of metalliform diversity can likely be explained by changes in heavy metal bioavailability that took place during large compositional changes of the earth's early atmosphere and oceans