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Although cagrilintide-semaglutide produced greater weight loss than either monotherapy alone in REDEFINE 1, the study design does not permit a formal assessment of pharmacological additivity or synergy

The overall very poor prognosis has recently led investigators to evaluate, in randomized clinical trials, the potential benefit of endovascular recanalization in patients with acute ischemic stroke due to a large vessel occlusion in the distal internal carotid artery and MCA M1 segment who have already a large core of infarction [Alberta Stroke Program Early CT Score (ASPECTS) 36 h) are believed to be related to the activation of brain-derived proteases such as MMP-9, neuroinflammation, and factors that promote vascular remodeling such as vascular endothelial growth factor (VEGF) (66)