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Higher glutathione was associated with shorter time to response ( F = 4.86, P = 0.017), while higher glutamate was associated with more severe functional impairment ( F = 5.33, P = 0.008)

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Our inability to precisely identify both the molecular mechanism and the relevant cell type(s) that mediate this phenotype are a weakness of this study, and future work should aim to address this in greater detail using in situ immunohistochemistry and single-cell sequencing