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While research supports its effectiveness and safety when used appropriately, individual responses can vary, and potential interactions with existing health conditions or medications must be considered

Oral bioavailability, which is the measure of drug exposure in systemic circulation following oral dosing compared against IV dosing using AUC calculation, is critical to understanding if low systemic concentration comes from either poor absorption, first pass metabolism, or both ( in vivo stability

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This is made even more problematic, given the number of factors that can deplete glutathione levels