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These subjects were invited to switch to first-generation e-cigarettes (Campagna et al., 2016

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Interestingly enough, a study found that freebase nicotine liquids can achieve a higher blood-nicotine level (2), indicating there could be advantages to freebase nicotine liquids including needing to vape less frequently, which in turn means spending less money and prolonging the lifetime of your rechargeable batteries, prefilled pods and e-liquid bottles