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Angiogenesis is defined as the formation of new blood vessels from existing vascular bed, It is a prime requirement in physiological processes such as wound healing and the menstrual cycle, on the other hand, it is an essential step for multiple pathological conditions, like cancer, macular degeneration, atherosclerosis, diabetic retinopathy, neovascular glaucoma, psoriasis and rheumatoid arthritis

Induction of this biosynthetic pathway enhances intracellular GSH levels and promotes cancer cell resistance to ferroptosis, 142,143 whereas pharmacological inhibition of GSH synthesis by L-buthionine-(S,R)-sulfoximine (BSO), a GCL inhibitor, induces ferroptosis 144

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