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The peptide reduces tumor necrosis factor-alpha (TNF-) and interleukin-6 (IL-6) expression in gastric tissue exposed to indomethacin, a known ulcerogen

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Native rhIGF-1 in IGF-1 Deficiency Chernausek et al., Journal of Clinical Endocrinology & Metabolism (2007) Chernausek and colleagues conducted the pivotal long-term clinical trial of recombinant human IGF-1 (mecasermin) in pediatric patients with severe primary IGF-1 deficiency the trial that supported FDA approval of Increlex for this rare growth-failure population