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This is particularly important because cannabis use is increasing, and conventional tobacco use is decreasing. Study background and details: Survey participants were ages 18-74, with an average age of 45 years

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Key to this approach are (i) the use of agreed reference products for comparison, ideally authorized MRTPs, and (ii) bridging methodologies that allow to compare a cMRTP with the reference products based on a limited number of studies (see challenge 4)