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Investigating how glutamine metabolism adapts to the constantly changing TME clues, such as hypoxia, acidosis, and nutrient deprivation, provides crucial insights into understanding immune cell function and resistance mechanisms [222, 223]

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TNF then activated two main inflammation-promoting pathways in the endothelial cells that line the million kidney filtering units, called glomeruli, in each kidney as well as the podocytes, cells that wrap around the tiny capillaries of the filtering units

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