what causes glutathione depletion Role of GSH in apoptosis and cytotoxicity . is an Chronic Glutathione Depletion Confers Protection

A lower GSH:GSSG ratio results in more oxidizing conditions (240 mV) [70] in the endoplasmic reticulum allowing protein disulfide formation

Higher doses, such as 15 mg/d, have also been tested in short-term studies, though these did not significantly increase plasma spermidine levels owing to pre-systemic conversion into other polyamines, such as spermine (Reference Senekowitsch, Wietkamp and Grimm20)

The review documented GSHs broad roles including antioxidant defence, nutrient metabolism, gene expression, DNA and protein synthesis, cell proliferation and apoptosis, signal transduction, cytokine production, immune response, and protein glutathionylation

The fix: verify that your specific peptide has documented sublingual bioavailability before choosing this route