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Butyrate acts blocks the IL-6/STAT3/IL-17 and TLR2-MyD88-NF-B pathways, and bidirectionally regulates cytokine secretion, Specifically, it upregulates anti-inflammatory factors such as IL-4 and IL-10 and downregulates pro-inflammatory factors such as CRP, IL-8, IL-12, and TNF- (66, 67, 91, 92)

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recommended daily allowance (RDA) is: 2.4 micrograms (mcg) per day Certain groups may require higher intake, including: Pregnant women: 2.6 mcg daily Breastfeeding women: 2.8 mcg daily Older adults Vegetarians and vegans Individuals with absorption issues 500 mcg to 5000 mcg , which is significantly higher than the RDA but still generally considered safe when medically supervised