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These include systemic medications such as methotrexate, cyclosporine, retinoids, 6-thioguanine, mycophenolate mofetil, troglitazone, and new biologic agents like adalimumab, alefacept, efalizumab, etanercept, and infliximab, as well as topical therapies like steroids, vitamin D analogues, psoralen, 5-aminolevulinic acid, salicylates, fumaric acid esters, anthralins (dithranol), tacrolimus, and retinoids, such as tazarotene

Therefore, our study suggests that nutritional supplementation of SAA metabolites, such as Ctt, H 2 S precursors, and taurine, might offer therapeutic strategies to increase the sensitivity of liver tumors to dietary intervention (e.g., methionine restriction) or chemotherapy

Amino acid metabolism in health and disease

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