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Importantly, we could not detect relevant amounts of CCR2+ cells (C-C chemokine receptor type 2, a typical marker of infiltrating monocytes and some neutrophil subsets [26]) although having established solid positive controls (Supplementary Fig

Finally, we showed that high-dose vitamin C therapy reduced both the number and size of tumors in KRAS or BRAF mutant mice as compared to mice without these mutations, confirming that vitamin C selectively targets KRAS or BRAF mutant tumors in mouse models of colon tumors

Impurities can introduce confounding variables that complicate the assessment of true 5-Amino-1MQ side effects

doi: 10.1016/j.freeradbiomed.2019.01.016 247 SchmittB.VicenziM.GarrelC.DenisF