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4.2.2 Resveratrol and curcumin nano-systems Natural compounds such as resveratrol and curcumin have long been recognized for their antioxidant and immunomodulatory effects, yet their therapeutic use is hindered by poor solubility, instability, and low bioavailability [50, 123]

Human or veterinary use is prohibited under regulations

It is hoped that this review will convince scientists and clinicians to look past paracellular permeability to other mechanisms by which endotoxin is taken into the body in the hope that interventions can be devised that prevent endotoxin uptake and that mechanistic interpretations of processes that increased paracellular permeability can be made

This arrangement creates a hydrophobic surface on DII formed by residues Y402, L404, V407 and L443 against which the helix is held by orienting a hydrophobic side formed by residues L97, L101 and I104 towards DII