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Antidepressant-like activity of oroxylin A in mice models of depression: a behavioral and neurobiological characterization

In one mouse study, researchers found that the peptide reduced the pain felt by the animals in their paws when placed on a mildly hot plate. The authors explained that this could be because GHK is similar in structure to cimetidine, a histamine H2 receptor antagonist sometimes given to reduce pain in certain digestive conditions.3 10 In rodents, doses as low as 0.5mg/kg were found to be effective in delivering these anti-pain effects.25 In a 70kg human, an equivalent dose would be around 5.6mg, though thats likely higher than necessary: pharmaceutical-grade GHK-Cu normally ranges from 0.5 mg to 2.5mg per injection

Delta-9 THC is the only cannabinoid for which there is a urinary threshold, and it is set at 150 ng/mL

But, theres a new kid on the block: peptide therapy, which promotes the bodys natural production of growth hormone