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The expression of the cystine/glutamate transporter is induced in the context of high oxidative stress and cell proliferation, ,, and its inhibition hinders glutathione synthesis leading to ferroptosis

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2) ( Reference Dong, Lisk and Block 33 ) , have been found to account for the anti-carcinogenic effect of Se-enriched broccoli and garlic, respectively, and have proved to be more effective in reducing colon and mammary tumorigenesis in rodents than selenate, selenite or Se-enriched yeast, which contains mostly SeMet ( Reference Ip, Birringer and Block 34 , Reference Finley, Davis and Feng 35 )