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Due to this fact, most cancer treatment involves combination therapies where each drug works by different mechanisms and thus diminishing the chance of developing resistance

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You might think you're administering a 1mg dose, but in reality, you're administering a fraction of that, along with a cocktail of unknown degradants

Altered expression of glutamate transporters, including the cystineglutamate transporter (xCT) system, increases concentrations of extracellular glutamate, which contribute to epileptic discharge, tumour proliferation and peripheral excitotoxicity