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For individuals experiencing mild gastrointestinal upset from B12 supplements (uncommon but possible with high doses), taking the supplement with breakfast may improve tolerance

Here are the best vitamin B12 injection sites for each method: Subcutaneous B12 injection sites Usually, the best places to give yourself a B12 shot subcutaneously are the abdomen, thigh, and upper arm, as you can see in this illustration: Although not shown above, the buttock is another good site for B12 shots