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It has been reported that the N-terminus of DAT is essential for protein kinase C-mediated phosphorylation on serine residues [67], and the first 22 amino acids from the N-terminus of DAT eliminate phosphorylation of DAT in response to PKC activation [44]

Liver PSAT1 is required for SAAR-induced improvements in systemic glucose homeostasis To assess whether hepatic serine synthesis is essential for the metabolic benefits of dietary SAAR on glucose control, we studied liver-specific PSAT1 KO mice and WT littermates fed a HF-CTRL or -SAAR diet (Fig

Moreover, TEC kinases are involved in TCR activation cascades in T cells identified in patients with AA, making their inhibition a relevant therapeutic target in this disease.8 Recently, the MoA of ritlecitinib and baricitinib has been reviewed in the context of AA pathophysiology

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